Acsl4 degradation
WebIt has been reported that in hepatic cells and primary cortical neurons, ACSL4 is degraded mainly through the proteasome pathway [34,35]. However, as previously hypothesized, …
Acsl4 degradation
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WebOct 30, 2024 · ACSL4 preferentially esterifies polyunsaturated fatty acids such as arachidonic acid. • AA induces ACSL4 degradation via the ubiquitin-proteasome … WebMar 18, 2024 · The ACSL4 protein can be recognized by the CMA receptor HSC70 and finally digested in lysosomes. However, abnormalities in the degradation process lead …
WebApr 14, 2024 · As expected, we found that CYP1B1 overexpression increased poly-ubiquitin chain linked-ACSL4 (Fig. 2H ), whereas CYP1B1 knockdown reduced the … WebNov 24, 2024 · Peroxisome-dependent and independent initiation of ferroptotic pathways. The peroxidation of PUFAs by ALOXs or POR to produce LOOH is an important step in promoting ferroptosis. The synthesis of ...
WebMar 19, 2024 · Identification of p115 as a novel ACSL4 interacting protein and its role in regulating ACSL4 degradation. Journal of Proteomics, Volume 229, 2024, Article 103926. Show abstract. Long-chain acyl-CoA synthetase 4 (ACSL4) is an ACSL family member that exhibits unique substrate preference for arachidonic acid. ACSL4 has a functional role in … WebMar 17, 2024 · 2.1. Identification of Tubastatin A as a novel ferroptosis inducer. To identify novel small molecule compounds that can induce ferroptosis in cancer cells, we constructed ferroptosis-resistant cell line which ferroptosis driving gene ACSL4 was knocked out in MDA-MB-231 and named MDA-MB-231-ACSL4-KO, and MDA-MB-231-ACSL4-WT was …
WebHepatic ACSL4 was significantly decreased in both of our NASH models and is also decreased by high-fat diet feeding in mice (36). Interestingly, free arachidonic acid causes ACSL4 to be...
WebMar 21, 2024 · ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) is a Protein Coding gene. Diseases associated with ACSL4 include Intellectual Developmental Disorder, X-Linked 63 and Stroke, Ischemic.Among its related pathways are Fatty acid metabolism and Integration of energy metabolism.Gene Ontology (GO) annotations related to this … flower designer indian gowns usaWebConsistent with free AA suppressing ACSL4 levels by promoting its ubiquitination and proteasomal degradation, 32 we found that ACSL4 was decreased in N27 cells after … flower design competition tv showWebMar 15, 2024 · Hepcidin acts by inducing endocytosis and subsequent degradation of FPN. The Tet1-RNF217-FPN axis, a newly recognized pathway, ... (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) are important enzymes responsible for the biosynthesis and remodeling of PUFA-phosphatidylethanolamines . flower designer san antonioWebCombined AA treatment with p115 knockdown suggested an additive role for p115 in AA-driven ACSL4 degradation. Furthermore, in vivo studies revealed a significant upregulation of p115 protein in the liver of mice fed a high fat diet that has been previously reported to induce downregulation of ACSL4 protein expression. This new finding has ... flower design for brother m280dWeb图2c-d：acsl4低表达的肺腺癌患者的无进展生存期（pfs）和总生存期（os）更差。 作者对tcga数据库中524例肺腺癌患者进行通路富集分析，值得注意的是，gsea和go富集分析 … flower design classes sfWebApr 12, 2024 · Our results revealed that lower level of ferroptosis-related proteins GPX4 in cartilage layer, but the level of ACSL4 and P53 increase in that of condyle. Injection of ferroptosis inhibitor liproxstatin-1 (Lip-1) effectively decrease ACSL4, P53 and … flower designer schoolWebOverexpression of ACSL4 results in a higher rate of arachidonoyl-CoA synthesis, increased 20:4 incorporation into phosphatidylethanolamine, phosphatidylinositol, and triacylglycerol, and reduced cellular levels of unesterified 20:4. Additionally, ACSL4 regulates PGE 2 release from human smooth muscle cells. greek tv show reunion