2024 Tanshinone iia sulfonate

Tanshinone iia sulfonate

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August undefined, 2024

WebMay 11, 2024 · Sodium tanshinone IIA sulfonate (STS; Fig. 1A) is a water-soluble derivative of tanshinone IIA. The latter is one of the primary lipophilic components extracted from … WebAug 17, 2015 · Approximately 60 patients with ST-segment elevation myocardial infarction successfully treated with primary percutaneous coronary intervention will be enrolled and randomized to receive the sodium tanshinone IIA sulfonate in addition to standard therapy or the same volume/day of normal saline.

Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone …

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Characterization and Stability of Tanshinone IIA Solid Dispersions …

WebSodium tanshinone IIA sulfonate (STS) has free radical scavenger properties which inhibited LDL oxidation resulting in the attenuation of cardiac cell hypertrophy [108]. The hydrophilic components also have antioxidant capacity by increasing activity of SOD and GPx and decreasing the level of MDA and ROS production significantly in vitro [109 ... WebApr 27, 2024 · Sodium Tanshinone IIA Sulfonate Acted as a Dual Inhibitor of Indoleamine 2,3-Dioxygenase 1 and Tryptophan 2,3-Dioxygenase 2. Considering the importance of IDO1 and TDO2 inhibitors in tumor immunotherapy, we developed an extracellular inhibitor screening model. First, we employed a prokaryotic protein expression system to produce … WebJan 10, 2024 · The anti-inflammatory actions of tanshinone IIA, which is the most important active component from Chinese herbal medicine Danshen, have been well studied. However, it remains unknown whether... swisstargetprediction打不开

Sodium tanshinone IIA sulfonate attenuates sepsis-associated …

Tanshinone IIA sulfonate protects against cigarette smoke

WebTanshinone IIa, cryptotanshinone and tanshinone I are three kinds of tanshinones which have been widely investigated. Particularly, sodium tanshinone IIa sulfonate is a water … WebJul 5, 2024 · Cryptotanshinone (CTS), tanshinone I (TSI) and tanshinone IIA (TSA) (Fig. 1) are the major lipophilic compounds of SM with diterpenoidal quinone structure 2 and sulfotanshinone sodium... swiss target prediction 平台WebOct 1, 2009 · In traditional Chinese medicine, tanshinone IIA is a lipid-soluble component of Danshen that has been widely used for various cardiovascular and cerebrovascular disorders, including neonatal asphyxia. Despite promising effects, little is known regarding the hemodynamic effects of tanshinone IIA in newborn subjects. To examine the dose … swisstargetprediction官网

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Tanshinone iia sulfonate

WebPrevious reports implied that tanshinone IIA (TSA) may offer potential benefits for Crohn's disease (CD). However, the detailed pharmacokinetic behavior of 掌桥科研一站式科研服务平台 WebNov 1, 2024 · Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative formed by the sulfonation of Tan-IIA. The introduction of sulfonic acid groups into STS considerably improved its water solubility and efficacy in the treatment of coronary heart disease, angina pectoris, and myocardial infarction.

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WebAbstract Background: Sodium tanshinone IIA sulfonate (STS) has been reported to protect organ function in sepsis. However, the attenuation of sepsis-associated brain injury and its underlying mechanisms by STS has not been established. WebTanshinone IIA, a diterpene quinone that originates from the roots of the traditional Chinese herb Salvia miltiorrhiza, is used as a treatment for CVD and columnar ectopy. 29 Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA, 30 and sodium tanshinone IIA sulfonate injection has been approved by the Chinese ...

WebSodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA isolated as the main pharmacologically active natural compound from a traditional Chinese herbal medicine, the dried root of … WebOct 2, 2024 · Salvia miltiorrhiza Bunge (Danshen) is a well-known Chinese Materia Medica for treating cerebral vascular and cardiovascular diseases in traditional Chinese medicine. Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA, which is the main active ingredient of Danshen.

WebApr 5, 2024 · Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA, which is the lipophilic diterpene that is isolated from the root of Salvia … WebOct 1, 2024 · Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivate of tanshinone IIA (Tan IIA) which is an active lipophilic constitute of Chinese Materia Medica …

WebOct 20, 2015 · The rationale for evaluating the ability of sodium tanshinone IIA sulfonate to reduce post-MI remodeling is based on experimental evidences indicating that tanshinone IIA is able to inhibit aberrant extracellular collagen matrix deposition and degradation triggered by the activated MMPs, which is a major determinant of the remodeling process ...

WebMay 15, 2024 · Sodium Tanshinone IIA Sulfonate (STS), one of the main active ingredients in Salvia miltiorrhiza, is a derivative of Tanshinone IIA (Tan IIA). Sodium sulfonate groups … swiss tamil partyWebApr 27, 2024 · Here, we discovered that sodium tanshinone IIA sulfonate (STS), a sulfonate derived from tanshinone IIA (TSN), reduced the enzymatic activities of IDO1 and TDO2 … swisstargetprediction数据库使用WebOct 7, 2011 · Tanshinone IIA (Tan IIA) is a member of the major lipophilic components extracted from the root of Salvia miltiorrhiza Bunge, which is currently used in China and other neighboring countries to treat patients suffering from myocardial infarction (MI), angina pectoris, stroke, diabetes, sepsis, and other conditions. However, Tan IIA is not … swiss target forecastWebMay 1, 2024 · However, the slow dissolution rate and poor oral bioavailability of Tan IIA hindered its clinical application. To improve its pharmacological activities, the derivatives of Tan IIA were designed [19].Through sulfonation at the C-16 position (Fig. 1 C), Sodium tanshinone IIA sulfonate (STS) was formed and significantly improved the water solubility … swisstargetprediction数据库怎么用WebTanshinone II A sulfonate is a water-soluble derivative of tanshinone II A that exhibits anti-inflammatory properties in rodent models of hepatitis and sepsis. Tanshinone II A sulfonate targets Ca 2+ -activated potassium channels and carboxylesterase 2. swisstargetprediction数据库介绍WebTanshinone II A sulfonate is a water-soluble derivative of tanshinone II A that exhibits anti-inflammatory properties in rodent models of hepatitis and sepsis. Tanshinone II A … swiss target prediction platformWebNov 14, 2024 · Tanshinone IIA, a diterpene quinone that originates from the roots of the traditional Chinese herb Salvia miltiorrhiza, is used as a treatment for CVD and columnar … swiss target prediction中文